Harvard Medical School
Jun Huh obtained his PhD from the California Institute of Technology and conducted his postdoctoral work at NYU School of Medicine as a recipient of the Jane Coffin Childs Memorial Fund Postdoctoral Fellowship. He received the NIH Pathway to Independence (PI) Award and the Smith Family Awards Program for Excellence in Biomedical Research. He was named a 2015 Searle Scholar and a 2016 Pew Scholar.
Huh’s laboratory studies mechanisms by which maternal inflammation leads to neurodevelopmental disorders in offspring. In mice, pregnant females infected with viruses or exposed to uncontrolled inflammation give birth to offspring that exhibit increased levels of anxiety, repetitive behaviors, and avoidance of social engagement – behavioral phenotypes that resemble the symptoms of autism spectrum disorder and/or schizophrenia. His lab has shown that a particular type of immune cell population in mothers called Th17 cells is involved in this process. In addition, they recently demonstrated that the bacterial community in the maternal gut plays an essential role in this model by promoting the differentiation of Th17 cells. Huh is also interested in identifying host- and bacteria-derived factors that regulate inflammation in the mammalian gut.